Question

Jose y Anita son los _____ de Padro y Roberto

Answer 1

The answer can be
Hijos, padres, amigos, tíos
Depending on further context.

Hijos- kids
Padres-Parents
Amigos-Friends
Tíos- aunt and uncle

Answer 2

padres, amigos

Explanation: Jose and Anita could be their parents or friends but without anymore details that's the two best answers I've got.