Question

Which of the following is true of the structure of typical transcriptional activators?

A.They contain only one type of motif.
B.The regulatory domain contains the DNA-binding motif.
C.The DNA-binding domain always binds to the coactivator.
D.They contain a regulatory domain that is functional when removed from the DNA-binding domain.

Answer 1

D.They contain a regulatory domain that is functional when removed from the DNA-binding domain.

Step-by-step explanation:

Transcriptional activators are transcriptional factors that positively regulate transcription of the gene (increase gene transcription). They usually contain two functional domains:

1. DNA-binding domain which interacts with DNA
2. Activation domain which interacts with other proteins.

Mechanism of action of activators includes their binding to the enhancers (DNA sequences) and recruitment of RNA polymerase II to the promoter.