Answer:
telomere replication problem
Explanation:
The telomeres are nucleoprotein structures that act to protect the extremities of linear chromosomes. At each cell division, the telomere becomes shorter due to its incomplete replication by conventional DNA polymerases. This genetic phenomenon is known as the 'telomere replication problem' (also called end-replication problem). Eukaryotic organisms fight against this problem by locating telomeres at the end of each linear chromosome (since telomeres are highly repeated hexameric nucleotide sequences).