Answer: Trade with the Venetians contributed to the fall of the Byzantine Empire in ways both direct and indirect. Because Venice was able to negotiate such favorable terms in their trade contracts with Constantinople, there arose bitter anti-Venice sentiment in the Eastern Empire. The Byzantines began harassing and imprisoning Venetian traders, leading to full-scale war. Venice was defeated, but the fraying, mismanaged Byzantine Empire was weakening from within and was vulnerable to the vengeful forces of the Venice-led Fourth Crusade.
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