Answer:
In the Southern Tidewater region, the best investment to make was in tobacco plantations.
Step-by-step explanation:
Tobacco plantations were in fact the only reason why the Jamestown colony did not fail after a very difficult first years. The climate of the region is very suitable for tobacco cultivation, and tobacco had a high enough demand in Europe to make the crop profitable.
This crop led to the growth of the Jamestown colony, and later on, of the Virginia Colony. Many settlers moved to the Virginia Colony, either to become owners of plantations, or to work in the plantations as indentured servants.