The correct answer to this open question is the following.
The similarities and differences between the Safavids and Ottomans lead to their constant struggle for power in that both empires aspire to have the power and control to conquer and rule more territories that could strengthen its presence in those lands. Although they had similarities, this factor made them natural rivals.
The Ottoman Empire was one of the most dominant empires of its time. It ruled over the lands of modern-day Hungary to parts of Arabia and the North of Africa. The Safavid Empire ruled over the lands of the Middle East. Regarding religion, the Ottomans were Sunni Muslims. The Safavids were Shiite Muslims. So these empires not only waged war due to control, power, and trade but also due to religious issues.