The correct answer to this open question is the following.
Although there are no options provided, we can say the following.
The most important problem the Ohio River Valley posed for the British officials was that many Native American Indian tribes lived along the river or that region and they favored or supported the French.
In a different approach to colonization, the French were not interested in conquering the Native American Indians' land,. The French were interested in the fur trade and making big profits. So the relationship with the Indians was good. Different case with the white English colonists that had all kinds of problems with the Indians.
Both French and English saw the Ohio River Valley as a strategic place due to the many raw materials and natural resources of the region and the key transportation issue throughout the Ohio River.