Evidence supporting E.coli DNA polymerase III having the major role in nucleotide incorporation during replication includes:
a) A point mutation can inactivate DNA pol III and inhibit replication.
b) DNA polymerase III has a high Vmax.
c) Replication is blocked at high temperatures in temperature sensitive mutants with a thermolabile form of DNA polymerase III.
d) There are ten or fewer molecules of enzyme per cell.
e) All of the above.