Question

4. There are a variety of receptors and second messenger systems in cells that in many cases exhibit cross-talk with each other (the activation of one can influence the behavior of another). Given this fact understanding how ligand activated receptors works is not as easy as presented in your book or in class. a. There are a number of different ligands that interact with their respective receptors. How do receptors for testosterone, ferro transferrin and Fibroblast Growth Factor differ from each other with respect to the location and function of their receptors

Answer 1

These 3 receptors are different from each other. They do differ from each other by their location and function.

1. Testosterone receptor : It is an Androgenic receptor

2. Ferrotransferrin receptor : It acts as an element-binding protein which is iron responsive.

3. Fibroblast growth factor : It acts as a growth factor.

Explanation:

1. Testosterone :

Location- Xq 11-12 in the X chromosome.

Function-

1. maintains male skeletal integrity by osteoblast and osteocytes.
2. maintains female sexual, somatic and behavior.
3. develops male sexual characters.

2. Ferrotransferrin :

Location- chromosome 3q21

Function-

1. intakes iron in the cell.
2. maintains the cellular iron equilibrium.
3. post-transcriptional modification.

3. Fibroblast (growth) :

Location- chromosome 4p16.3

Function-

1. helps in bone development.
2. helps in bone growth maintenance by ossification.