Question

Which of the following outcomes could potentially result if a mutation in the gene encoding the G? subunit eliminates its GTPase activity? Choose three outcomes.1. The cell would be unresponsive to molecules that act via cAMP.2. The rate of GTP hydrolysis would increase.3. The signaling pathway could be activated for an extended period, possibly resulting in undesirable cell proliferation.4. The concentration of cAMP in the cell would be continuously elevated.5. The concentration of cAMP in the cell would be continuously elevated.6. G? would be ineffective as a signal molecule (that is, it could not activate other proteins).7. G? would be activated for an extended period.

Answer 1

The three outcomes that could potentially result if a mutation in the gene encoding the the Gα subunit eliminates its GTPase activity are number 3, 4 and 7 which are;

The signaling pathway could be activated for an extended period, possibly resulting in undesirable cell proliferation.

The concentration of cAMP in the cell would be continuously elevated.

Gα would be activated for an extended period.