Question

Cellular signaling follows a cascade of events and has multiple points of regulation. Which of the following could be a reason(s) why a signalling cascade is interrupted, or turned 'off', once it has been turned 'on'?

A. The ligand is prevented from reaching the binding site.
B. A chemical modification occurred on serine, threonine, or tyrosine side chains to turn on/off proteins.
C. A protein gets tagged with an ubiqutin group and gets degraded.
D. A G-binding protein binds to a GTP molecule.
E. A, B and C only.
F. A and B only.
G. All of the above.

Answer 1

A,B and c only

Step-by-step explanation:

Cell signalling is the transfer of information from one cell to another.

It is important for growth, development and immunity.

An error can lead to serious problems such as diabetes and cancer.

Therefore this process is highly regulated. A signal in the cascade can be interrupted or turned off when;

• The ligand is prevented from reaching the binding sites
• A chemical modification occurred on serine, threonine, or tyrosine side chains to turn on/off proteins.
• A protein gets tagged with an ubiqutin group and gets degraded.