Question

In terms of base nucleotides, explain the only difference between the DNA message for normal hemoglobin and the DNA message for sickle-cell hemoglobin.

Answer 1

In the 1950s, Vernon Ingram demonstrated that the only structural difference between normal adult hemoglobin and sickle-cell hemoglobin is the replacement of glutamic acid with valine in the β-globin amino acid chain (Ingram, 1957; 1959).

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