Margaret, a twenty-year-old student, says that she hears a voice constantly saying the phrase "Usher, I would like a seat from which I can see the pianist." Also, she is convinced that she is a creature from another planet sent to Earth to prepare for an alien invasion. Furthermore, Margaret often speaks in rhymes and uses nonsense words that others cannot understand. Some researchers who study the biological bases of psychopathology suggest that the __________ in Margaret’s brain shows __________ activity.