Question

How did smallpox spread to the America’s in the 16th century?

Answer 1

Step-by-step explanation:

16th Century—European settlers and the African slave trade import smallpox into: The Caribbean. Central and South America.

Answer 2

Explanation: Smallpox is believed to have arrived in the Americas in 1520 on a Spanish ship sailing from Cuba, carried by an infected African slave. As soon as the party landed in Mexico, the infection began its deadly voyage through the continent.