In the first number, the 6 is in the tens place. It represents 60.
The second number has the 6 in the hundreds place. It represents 600.
The 6 in the second number is ten times greater than the 6 in the first number.
It might help to expand each number out
- 543,862 = 500,000 + 40,000 + 3,000 + 800 + 60 + 2
- 385,621 = 300,000 + 80,000 + 5,000 + 600 + 20 + 1
And it should be more clear what the connection is.