Question

Dna is more resistant to hydrolysis than rna. What feature of dna is responsible for this characteristic?.

Answer 1

The presence of a 2'-hydroxyl group in RNA

Deoxyribose does not include a 2′-hydroxyl group. The reason RNA is more susceptible to hydrolysis is because it has a 2'-hydroxyl group. The 3'-phosphate may be attacked by the 2'-OH, which might cause the phosphodiester link to be hydrolyzed.