Answer and Explanation:
It is likely that you are referring to the colonization of Mars. If this is the case, we can say that the colonists, in relation to physical problems, the colonists will present problems related to the atmosphere, temperature and even food. These problems can extend over the long or medium term, but they can be easy to deal with as technology advances.
On the other hand, settlers must face psychological problems related to loneliness, uncertainty and fear and these can be difficult to deal with due to the complexity that these problems present and the unavailability of treatment away from the Earth.