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Answer:
Option 3: the cells express different genes.
Step-by-step explanation:
While all cells contain the same genes (the DNA does not change based on cell function), cells can choose to express different genes during the differentiation process so they become specialized for different functions.
In this case, skin cells may begin to develop with high concentrations of strengthening proteins such as keratin and collagen, in order to carry out their main functions e.g. to act as a strong barrier against parasites, bacteria, etc.
Whereas muscle cells may have less of these proteins because their function is different, and instead may focus on developing more mitochondria to provide energy to carry out their main jobs (movement).