Question

Which of the following disease-causing classes in CF does the CFΔF508 mutation exhibit? A. Only Class II B. Class II & Class III C. Class II & Class IV D. Class II & Class V E. Class II, III, IV and V

Answer 1

The CFΔF508 mutation is a Class II mutation affecting the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Patients with CF exhibiting this mutation have a defective channel protein that is degraded instead of being incorporated into the membrane.

Step-by-step explanation:

The CFΔF508 mutation exhibits Class II disease-causing class in cystic fibrosis (CF). Class II mutations result in the protein being processed incorrectly and typically not incorporated into the cell membrane, often being degraded by the cell. This aligns with the CFTR protein malfunction in cystic fibrosis, where the defective protein fails to regulate the transport of chloride ions properly, leading to the classic symptoms of the disease. As for Zoe, the most likely explanation for her cystic fibrosis is inheriting faulty alleles from both parents, each carrying one copy of the mutated gene, making them carriers of the disease.