The Missouri Compromise was a significant political compromise in the early history of the United States, as it allowed for the balance of power between Northern and Southern states in the Senate, while also limiting the expansion of slavery into the Western territories. Since the compromise allowed for the admittance of one free state and one slave state at a time, it ultimately favored the South, as they were able to maintain their majority in the Senate for several decades.
The compromise had a significant impact on the larger states because it maintained the balance of power between the North and the South, allowing both regions to continue their economic and social development while also addressing the issue of slavery in the Western territories. However, it also created significant tensions and disagreements, as the two regions had different interests and values, and these differences became more pronounced as time went on. In the end, the Missouri Compromise was a significant political compromise that ultimately played a role in the lead up to the American Civil War.