Final answer:
Among the given drug options, Lisinopril is considered non-nephrotoxic, meaning it does not contribute to kidney damage. Instead, as an ACE inhibitor, it helps to lower blood pressure by causing blood vessels to relax.
Step-by-step explanation:
When evaluating the impact of medications on the etiology of ARF (acute renal failure), it's important to distinguish between nephrotoxic and non-nephrotoxic medications. Amongst the given options, lisinopril is the drug considered to be non-nephrotoxic. Whereas, Ibuprofen, Vancomycin, and Gentamicin are known to have nephrotoxic effects.
This means that unlike the other three drugs, Lisinopril does not directly cause damage to the kidneys. As an angiotensin-converting enzyme (ACE) inhibitor, it works to lower blood pressure by relaxing blood vessels - not via the nephrotoxic influence on the loop of Henle like some oliguric drugs.
Learn more about Nephrotoxic Drugs