Answer:
One of the key developments in the early 1800s that led to political conflicts between Northern and Southern states in the United States was the issue of slavery. As the nation expanded westward, disputes arose over whether newly admitted states would allow slavery or not. The Missouri Compromise of 1820 and the Compromise of 1850 were attempts to address these conflicts, but they ultimately highlighted the deep divides between the North and South on issues related to slavery and states' rights. These conflicts over slavery and its expansion into new territories eventually played a significant role in the lead-up to the American Civil War in the 1860s.
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