Final answer:
To prepare 30mL of a 1% w/v isotonic Fentanyl Citrate solution with an E value of 0.11, you would require 26.33 mL of purified water and 3.67 mL of isotonic NaCl solution.
Step-by-step explanation:
To calculate how many milliliters each of purified water and an isotonic sodium chloride solution should be used to prepare 30mL of a 1% w/v isotonic solution of Fentanyl Citrate with an E value of 0.11, you need to account for the volume of sodium chloride in the isotonic solution required to make the fentanyl citrate solution isotonic.
To start, you need to determine the amount of Fentanyl Citrate needed for a 1% w/v solution. For 30 mL of solution, you need 0.3 g of Fentanyl Citrate (since 1% w/v is 1g/100mL). Given the E value (0.11), you calculate the required amount of NaCl to make the solution isotonic by multiplying 0.3 g by 0.11, which gives you 0.033 g NaCl.
To find out the volume of the isotonic NaCl solution to add, we need the concentration of isotonic NaCl solution. Assuming we are using a standard isotonic (0.9% w/v) NaCl solution, this equates to 9g/L. Thus, the required volume of isotonic NaCl solution is 0.033g / (9g/L) = 0.00367 L, or 3.67 mL.
The rest of the volume up to 30 mL will be purified water. Since you are adding 3.67 mL of NaCl solution, you need 30 mL - 3.67 mL = 26.33 mL of purified water.
Therefore, the correct answer is C. 26.33 mL of purified water & 3.67 mL of NaCl solution.