To calculate the amount of concentrate needed in the 5-gallon sprayer, we need to convert the volume of the sprayer from gallons to liters. 
Since 1 gallon is approximately 3.785 liters, 5 gallons would be approximately 5 * 3.785 = 18.925 liters. 
Now, we can use the recommended rate of 12 mL concentrate per 5L of water to determine the amount of concentrate needed. 
Using a proportion, we can set up the equation: 
12 mL / 5 L = x mL / 18.925 L 
Cross-multiplying, we get: 
5 * x mL = 12 * 18.925 mL 
Simplifying, we find: 
x ≈ 45.42 mL 
Rounding to the nearest hundredth, the amount of concentrate needed in the 5-gallon sprayer is approximately 45.42 mL.