Final answer:
To make 100 mL of the drug solution isotonic with an E value of 0.4, you would need 0.04 grams of the drug.
Step-by-step explanation:
To calculate the amount of grams of the drug necessary to make the 100 mL solution isotonic, we need to know the E value of the drug. The E value represents the osmotic pressure of the substance. In this case, the E value is given as 0.4. To calculate the number of grams, we can use the equation: E value = (grams of solute) / (volume of solution in liters). Rearranging the equation to solve for grams of solute, we can calculate grams of solute = E value × volume of solution in liters. Since the volume of the solution is given as 100 mL, we need to convert it to liters by dividing by 1000. Plugging in the values, we get grams of solute = 0.4 × (100/1000) = 0.04 g. Therefore, 0.04 grams of the drug are necessary to make 100 mL of the solution isotonic.