Question

A genetic mosaic is an organism with two or more populations of cells that differ in genotype. The authors of this study asked the question, "Is smoking associated with a man's degree of mosaic loss of the Y chromosome (LOV) ?" Here, mosaic LOY refers to a man who has cells that possess a Y chromosome, and cells that lack a Y chromosome. Why the authors think this was an important question to answer? Select all that apply. Hint: The Abstract provides an overview of the content of the paper and the "Previous work" learning lens highlights the foundational research on which this paper builds. a. Researchers do not know why malos have a higher incidence of mortality from most non-sox-specific cancers than women do.

b. Smoking is a significant risk tactor for cancers, including those outside the rospiratory tract c. They wanted to identify the mechanism by which Y chromosomes are lost by some colis d. LOY in blood cells is associated with increased risk of certain kinds of tumors e. Understanding why some mon lose the Y chromosome in some of their cells may help explain why those men have infertility problems f. An earlier study by these authors found that LOY is the most commonly acquired (not inherited) mutation in the groups of men they studied

Answer 1

The authors asked whether smoking is associated with a man's degree of mosaic loss of the Y chromosome (LOY) and its potential implications on health.

Step-by-step explanation:

The authors of this study asked the question of whether smoking is associated with a man's degree of mosaic loss of the Y chromosome (LOV). They wanted to identify the mechanism by which Y chromosomes are lost in some cells and how it may be related to smoking. The authors also found that LOY in blood cells is associated with an increased risk of certain kinds of tumors. Understanding why some men lose the Y chromosome in some of their cells may help explain infertility problems in those men.

Answer 2

The study asks if smoking is associated with loss of the Y chromosome in cells, which is important for understanding male-specific cancer mortality, the impact of environmental factors like smoking on genetic changes, and identifying mechanisms of Y chromosome loss.

Step-by-step explanation:

The authors of the study which focuses on the genetic mosaic concept, specifically Loss of the Y chromosome (LOY) in cells, have posed the question: "Is smoking associated with a man's degree of mosaic LOY?" This inquiry holds importance due to several reasons. First, it aims to address a gap in understanding why males have a higher incidence of mortality from non-sex-specific cancers compared to females (Researchers do not know why males have a higher incidence of mortality from most non-sex-specific cancers than women do). Secondly, since smoking is a well-established risk factor for cancers (Smoking is a significant risk factor for cancers), the study could link environmental factors with genetic changes. Finally, the study seeks to explore a potential mechanism behind LOY (They wanted to identify the mechanism by which Y chromosomes are lost by some cells), which could further our understanding of the genetic underpinnings of disease susceptibility.