Question

Imagine a cell had a version of helicase that was permanently stuck at the origin of replication. Would this be considered a dominant negative mutant and why? Only one of the explanations below is correct (among the last 4 answer choices)

a yes...since it will prevent normal helicases from functioning.
b no...because it is an inactive protein.
c only if it was the only version of helicase in the cell.
d Yes...because there would be excess DNA replication.

Answer 1

Answer: A. yes...since it will prevent normal helicases from functioning.

Explanation: Imagine a cell had a version of helicase that was permanently stuck at the origin of replication. It would be considered a dominant negative mutant since it will prevent normal helicases from functioning.