Question

Which medications are included in first-line therapy for heart failure? (Select all that apply.)

a. Agents that inhibit the renin-angiotensin-aldosterone system (RAAS)
b. Aldosterone antagonists
c. Beta blockers
d. Cardiac glycosides
e. Diuretics

Answer 1

Answer: A, D, B

Explanation:

Major trials analyzing ACE inhibitors in HFrEF have utilized them in addition to standards of care such as digoxin, vasodilators, loop diuretics, potassium-sparing diuretics, and beta blockers.7–10 The CONSENSUS trial, which compared enalapril with placebo in addition to standard of care, showed that enalapril reduced overall mortality risk by 27% and significantly decreased the number of patients with HFrEF progression.