Answer:
Macrophages and T cells activate the two primary cells responsible for granuloma formation in TB.
Step-by-step explanation:
the two primary cells responsible for granuloma formation in TB are macrophages and T cells. Macrophages ingest and present M. tuberculosis antigens to T cells, which secrete cytokines that activate macrophages and recruit more immune cells to the site of infection. The interaction between macrophages and T cells leads to the formation of a granuloma, a structure that contains and isolates the bacteria from the surrounding tissue. Therefore, the answer is: Macrophages and T cells activate the two primary cells responsible for granuloma formation in TB.