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what is the biochemical explanation for the observed toxic effects of arsenic conrtaiminated well water in bangladesh

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User Pfunc
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Answer:

  • Arsenic is converted to arsenite, which covalently modifies reduced lipoamide, thereby inhibiting the activity of the pyruvate dehydrogenase complex and blocking the conversion of pyruvate to acetyl-CoA OR The arsenic-contaminated well water caused inhibition of dihydrolipoyl transacetylase, which is an enzyme subunit required for the metabolism of rice starch, the source of 70% of their daily caloric intake.

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User Bull
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