To simplify 6x8y ÷ -3x2y2, we first need to divide the coefficients and simplify the variables separately.
Dividing 6 and -3 gives us -2.
For the variables, we subtract the exponents of x and divide them, which gives us x^(8-2) or x^6.
We also subtract the exponents of y and divide them, which gives us y^(1-2) or y^-1. To simplify y^-1, we move the variable to the denominator and make it y^1 or simply y.
Therefore, our final answer is -2x^6y.
So, 6x8y ÷ -3x2y2 = -2x^6y