Answer:
The main difference between the two is in the site of action, with ACE inhibitors acting upstream by inhibiting the formation of angiotensin II, and ARBs acting downstream by blocking the action of angiotensin II on its receptor. ACE inhibitors and ARBs both act on the renin-angiotensin-aldosterone system to lower blood pressure. ACE inhibitors block the conversion of angiotensin I to angiotensin II, while ARBs block the action of angiotensin II on its receptor. This difference in mechanism of action can have clinical implications in terms of efficacy and side effect profiles, and the choice of therapy depends on individual patient factors and the presence of comorbidities.
Step-by-step explanation: