Question

what happens when a b-cell receptor binds an self/autoantigen in the bone marrow? the b-cell group of answer choices undergoes apoptosis (cell death). produces antibodies. proliferates (divides). develops into a memory cell. develops into a plasma cell.

Answer 1

When a B-cell receptor binds a self/autoantigen in the bone marrow, the B-cell group undergoes apoptosis (cell death). This process is called negative selection, and it is a critical mechanism for preventing the development of autoimmunity. B-cells that recognize self-antigens with high affinity are eliminated through apoptosis to prevent them from producing autoantibodies.