The process of Florida becoming a state and the events leading up to it were similar to those of the Missouri Compromise in several ways:
Both involved the issue of slavery: In the case of the Missouri Compromise, the issue was whether slavery would be allowed in the new state of Missouri and in the territories west of the Mississippi River. In the case of Florida, the issue was whether the state would be admitted as a slave state or a free state.
Both involved a compromise: The Missouri Compromise was a compromise between the pro-slavery and anti-slavery factions in Congress, which allowed Missouri to enter the Union as a slave state and Maine to enter as a free state. It also established a line (the 36°30′ parallel) beyond which slavery would be prohibited in the territories. Similarly, in the case of Florida, a compromise was reached that allowed the state to enter the Union as a slave state in exchange for the admission of Iowa as a free state.
Both were part of the larger debate over the expansion of slavery: The Missouri Compromise was part of a larger debate over the expansion of slavery into new territories, while the admission of Florida as a slave state was part of a larger debate over the expansion of slavery into the new territories acquired in the Mexican-American War.
Both were controversial and divisive: The Missouri Compromise was controversial and divisive, with both sides accusing the other of trying to impose their views on the other. Similarly, the admission of Florida as a slave state was controversial and divisive, with many Northerners opposing it and many Southerners supporting it.
In summary, both the process of Florida becoming a state and the events leading up to it had similarities with the Missouri Compromise, as they both involved the issue of slavery, a compromise, a larger debate over the expansion of slavery, and controversy and division.