Answer:
The GCF of 16 and 40 is 8. To calculate the greatest common factor of 16 and 40, we need to factor each number (factors of 16 = 1, 2, 4, 8, 16; factors of 40 = 1, 2, 4, 5, 8, 10, 20, 40) and choose the greatest factor that exactly divides both 16 and 40, i.e., 8.