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Ozone Depletion. When chlorine and bromine atoms come into contact with ozone in the stratosphere, they destroy ozone molecules. One chlorine atom can destroy over 100,000 ozone molecules before it is removed from the stratosphere.
Ozone depletion can cause increased amounts of UV radiation to reach the Earth which can lead to more cases of skin cancer, cataracts, and impaired immune systems.
Too much exposure to UV is believed to be contributing to the increase in melanoma, the most fatal of all skin cancers.