Final answer:
The Tau protein needs to be properly phosphorylated to maintain the structural integrity of the microtubule assembly.
Step-by-step explanation:
True. The Tau protein needs to be properly phosphorylated in order to maintain the structural integrity of the microtubule assembly. Phosphorylation is a process in which a phosphate group is added to a protein, and in this case, when Tau becomes phosphorylated, it binds to and stabilizes microtubules.
However, when Tau becomes hyper-phosphorylated, its conformation changes, leading to the disassembly of microtubules and the formation of neurofibrillary tangles.