Question

Myeloid and lymphoid cells are derived from pluripotential stem cells. Cytokines capable of inducing growth of hematopoietic cells in vitro were initially characterized using cultures of bone marrow cells grown in soft agar and are thus referred to as colony-stimulating factors. One of these factors is granulocyte colony-stimulating factor (G-CSF), which supports the clonal growth of granulocytes. G-CSF utilizes what family of cytokine receptors?

Immunoglobulin superfamily
TNF
MAGE
Ras
Class I

Answer 1

G-CSF utilizes the Class I cytokine receptor family to support the growth of granulocytes from pluripotent stem cells.

Step-by-step explanation:

Granulocyte colony-stimulating factor (G-CSF) is a cytokine that supports the clonal growth of granulocytes from pluripotent stem cells. G-CSF functions by interacting with a specific family of cytokine receptors. The family of cytokine receptors utilized by G-CSF is known as the Class I cytokine receptor family, also called hematopoietin family receptors.

These receptors are characterized by their ability to bind various cytokines, which are critical in the regulation of blood cell production and immune system function. The activation of these receptors leads to a cascade of events promoting the survival, proliferation, and differentiation of myeloid cells into granulocytes.