Question

Eotaxins are CC chemokines that attract eosinophils, Th2 lymphocytes, and basophils. There are two eotaxins, eotaxin-1 and eotaxin-2, which share similar activities although they share little homology. Eotaxins are produced by epithelial cells, endothelial cells, and eosinophils, and their expression is enhanced in allergic inflammation. Thus, eotaxins are thought to play an important role in allergy and asthma. What is the receptor for eotaxins?

a) CCR3
b) CCR5
c) CXCR4
d) Mac-1
e) SDF-1

Answer 1

The receptor for eotaxins, which are instrumental in recruiting responders to allergic reactions, is CCR3.

Step-by-step explanation:

The receptor for eotaxins, which are chemokines that play a crucial role in the recruitment of eosinophils, Th2 lymphocytes, and basophils particularly during allergic inflammation and asthma, is CCR3. Eotaxin-1 and eotaxin-2, despite sharing little homology, have similar activities and bind to the CCR3 receptor on the target cells.

This binding facilitates the migration of these cells to sites of inflammation, contributing to the immune response seen in allergic reactions and parasitic infections.