Question

IgE is mostly found fixed in the tissues on mast cells that bear receptors for it, as well as on circulating basophils and activated eosinophils. The ligation of cell-bound IgE by antigens such as pollen or mold triggers activation of these cells at the site of antigen entry into the tissues. The release of inflammatory lipid mediators, cytokines, and chemokines at sites of IgE-triggered reactions results in the recruitment of eosinophils and basophils to augment what response?

Wheal-and-flare reaction
Type I hypersensitivity
Type II hypersensitivity
Type III hypersensitivity
Urticaria

Answer 1

The recruitment of eosinophils and basophils in the presence of IgE antibodies in response to allergens like pollen or mold augments the 2) Type I hypersensitivity response, an immediate allergic reaction mediated by mast cell degranulation.

Step-by-step explanation:

When IgE is fixed in the tissues on mast cells and bound by antigens such as pollen or mold, it triggers the activation of these cells at the site of antigen entry into the tissues.

The release of inflammatory lipid mediators, cytokines, and chemokines at the site of IgE-triggered reactions results in the recruitment of eosinophils and basophils to augment the 2) Type I hypersensitivity response.

This response is immediate and is caused by the crosslinking of the antigen-specific IgE molecules on the mast cell surface, leading to degranulation and the release of vasoactive substances such as histamine and cytokines that promote inflammation and the symptoms of allergic reactions.