Question

As a result of gene rearrangement, what does each B cell produce?

A diverse spectrum of antibodies of various specificities
An antibody of a single specificity
No antibodies
A restricted set of different antibodies
Both kappa and lambda light chains and a single heavy chain

Answer 1

Each B cell produces an antibody of single specificity due to gene rearrangement involving V, D, and J segments, which leads to a unique antigen-binding site for each antibody produced. Option B.

Step-by-step explanation:

As a result of gene rearrangement, each B cell produces an antibody of a single specificity.

This process occurs through the random excision and splicing of variable (V), diversity (D), and joining (J) segments from the light and heavy chain genes. The heavy chain's variable region is made up of V, D, and J segments, while the light chain's variable region is made up of V and J segments.

Upon maturation, a B cell undergoes DNA rearrangements to create a unique antigen-binding site, contributing to the vast diversity of antibodies that the immune system can produce.

Each B cell then differentiates to secrete large quantities of antibodies with a unique variable region capable of binding to a specific antigen, while the constant region which does not bind to the antibody remains the same for all antibodies of a particular class. So Option b.