Final answer:
IgE antibodies are bound to mast cells, basophils, and eosinophils and play a significant role in allergic reactions through the release of inflammatory substances.
Step-by-step explanation:
IgE antibodies are known for their role in allergic reactions and are bound to mast cells primarily. Apart from mast cells, IgE can also be found on two other types of cells which are basophils and eosinophils. These cells have receptors on their surface that specifically bind to the Fc region of IgE.
When allergens enter the body, they can bind to the IgE on the surface of these cells, leading to the degranulation of the cells and the release of inflammatory mediators like histamine. This process plays a significant role in the development of allergic symptoms such as vasodilation, edema, rash, hay fever, and asthma.