Question

Describe the NF-KB ending intracelullar signaling pathways ending TFs that get triggered upon B cell activation

Answer 1

The NF-KB signaling pathway is triggered upon B cell activation and involves the activation of specific genes that promote the immune response.

Step-by-step explanation:

The NF-KB signaling pathway is involved in the activation of B cells. B cell activation occurs in response to interaction between the B cell receptor (BCR) and its matching antigen. Here's how the NF-KB signaling pathway is triggered upon B cell activation:

1. A ligand binds to NF-KB, activating it and allowing it to enter the nucleus and stimulate transcription.
2. Phosphorylation of the inhibitor IK-B dissociates the complex between it and NF-KB, enabling NF-KB to enter the nucleus.
3. Once inside the nucleus, NF-KB promotes the transcription of specific genes related to B cell activation.

This signaling pathway ultimately leads to the production of proteins that are involved in the immune response and memory formation.