Final answer:
Creatine supplementation can lead to side effects such as cramping, diarrhoea, and weight gain due to increased cell volumization and water drawn into the muscles.
Step-by-step explanation:
The known side effects of Creatine supplementation can include cramping, diarrhoea, and weight gain. Creatine primarily works by increasing cell volumization, which draws water into muscle cells and enlarges them. While creatine is beneficial in increasing muscle mass and strength, it can lead to certain gastrointestinal disturbances such as stomach cramps, bloating, increased gas, and nausea. Additionally, increased water retention within the muscle cells may contribute to weight gain, but this is a result of the muscles holding more water rather than fat accumulation. It's important to note these side effects vary among individuals and are often dose-dependent.