Final answer:
The state with Charleston at the confluence of the Ashley and Cooper Rivers, named after King Charles II of England, known as the Holy City, and with Fort Sumter and Fort Moultrie, as well as cities like Greenville and Spartanburg, is South Carolina.
Step-by-step explanation:
The state you are referring to is South Carolina. Charleston, also known historically as Charles Town, is situated at the confluence of the Ashley and Cooper Rivers, which forms its harbor. The city was named in honor of King Charles II of England and is known as the 'Holy City' due to its numerous church steeples. It is also home to the historical Fort Sumter and Fort Moultrie in its harbor, and the cities of Greenville and Spartanburg are also located in South Carolina.
In the colonial period, Charles Town became an essential seaport and was the southernmost in English hands after the Spanish captured Port Royal. Due to its strategic importance and vulnerability to attack from the sea, the city was fortified against the Spanish, the French, and pirates like Edward Teach, otherwise known as Blackbeard. Fort Sumter is notable for being the site where the first shots of the Civil War were fired on April 12, 1861.