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Which antibiotic, produced by Streptomyces spp., has a broad spectrum (gram-positive, gram-negative, anaerobes), contains a B-lactam ring and a modified 'thiazolidine ring,' and inhibits cell wall synthesis by binding to penicillin-binding proteins, stimulating autolysins?

A. Penicillin
B. Cephalosporin
C. Vancomycin
D. Amoxicillin

1 Answer

2 votes

Final answer:

The antibiotic with a broad spectrum, containing a β-lactam ring and a modified 'thiazolidine ring' that inhibits cell wall synthesis by binding to penicillin-binding proteins is Cephalosporin.

Step-by-step explanation:

The antibiotic that is produced by Streptomyces spp., has a broad spectrum (including gram-positive, gram-negative, and anaerobic bacteria), contains a β-lactam ring and a modified 'thiazolidine ring,' and inhibits cell wall synthesis by binding to penicillin-binding proteins while stimulating autolysins is Cephalosporin.

Similar to the penicillins, Cephalosporins contain a β-lactam ring and block the transpeptidase activity of penicillin-binding proteins. The structure of Cephalosporins, particularly Cephalosporin C, includes a β-lactam ring fused to a six-member ring which grants it increased resistance to enzymatic inactivation by β-lactamases. Notably, Cephalosporin C has two R groups which allow for greater diversity in chemical alterations compared to penicillins which only have one R group. This diversity has led to the development of a range of semisynthetic cephalosporins that are categorized into generations based on their spectrum of activity.

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User Larvyde
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