Question

3 agents that denature proteins or attach to their active site to prevent substrate from interacting:

a) Aminoglycosides, Macrolides, Sulfonamides
b) Beta-lactams, Glycopeptides, Rifamycins
c) Quinolones, Nitrofurans, Isoniazid
d) Echinocandins, Azoles, Allylamines

Answer 1

Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.

Step-by-step explanation:

Aminoglycosides, macrolides, and sulfonamides are three agents that denature proteins or attach to their active site to prevent substrate from interacting.

• Aminoglycosides are large, highly polar antibacterial drugs that bind to the 30S ribosomal subunit, impairing the proofreading ability and causing mismatches between codons and anticodons.
• Macrolides such as erythromycin, azithromycin, and clarithromycin bind to the 50S ribosomal subunit and prevent peptide bond formation, stopping protein synthesis.
• Sulfonamides such as sulfamethoxazole and trimethoprim interfere with bacterial folic acid synthesis as antimetabolites.