Final answer:
Combined alpha-beta antagonists aid in the management of heart failure by dilating blood vessels and slowing heart rate, improving cardiac function and helping with arrhythmias and hypertension.
Step-by-step explanation:
Combined alpha-beta antagonists are used to reduce the progression of heart failure because they block the receptors associated with vasoconstriction and cardioacceleration. By targeting both α and β receptors, these drugs work to dilate blood vessels and slow heart rate, which can significantly improve cardiac function in patients with conditions such as congestive heart failure or those who have suffered a heart attack. Medications like metoprolol and propranolol are commonly used; metoprolol selectively blocks the β1-receptor, while propranolol is a nonselective blocker of β-receptors. Additionally, these antagonists can be beneficial in treating arrhythmias and in managing hypertension.