Final answer:
The most important barrier to mitigating the over-exploitation of game meat is the strong enforcement of regulations, as this is necessary for the success of any measures like fines or no-take areas.
Step-by-step explanation:
The single most important barrier to mitigating the over-exploitation of game meat is robust enforcement of national legislation. Bioeconomic models suggest that imposing large fines on commercial sale of wildlife can help, but this requires a solid framework for enforcement. The effectiveness of such regulations heavily depends on the existence of strong, non-corrupt regulatory institutions capable of enforcing fines or bans on hunting and trade. Without political will and enforcement capability, fines and no-take areas have limited impact, especially in regions with poor governance or where subsistence hunting is the norm. Therefore, establishing a reliable and effective enforcement mechanism is critical to the success of mitigating over-exploitation.