Question

In mutations, what is the wildtype allele, what are LOF and GOF alleles?

A) Wildtype: most common allele; LOF: Loss-of-function; GOF: Gain-of-function
B) Wildtype: least common allele; LOF: Low-level function; GOF: Growth of function
C) Wildtype: mutated allele; LOF: Limited-off function; GOF: Greater-off function
D) Wildtype: reference allele; LOF: Lower-off function; GOF: Greater-off function

Answer 1

The correct response is that the wildtype allele is the most common, LOF stands for Loss-of-function, and GOF stands for Gain-of-function.

Step-by-step explanation:

In mutations, the wildtype allele refers to the most common phenotype or genotype found in a natural population, which functions at a capacity sufficient to sustain life. It is considered the standard against which mutations are compared. Alleles revolve around variations from this wildtype, resulting in either loss-of-function (LOF) mutations that reduce or eliminate the function of the gene product, or gain-of-function (GOF) mutations that increase the function or cause it to appear in new times and/or places, potentially resulting in a dominant negative effect if the mutation interacts adversely with the wild-type gene product.